François de Bourbon, Count of Enghien (23 September 1519 – 23 February 1546) was a French prince of the blood. He was the son of Charles de Bourbon, Duke of Vendôme.
Given command of the French army in Italy by Francis I of France during the Italian War of 1542, he was the French commander at the Franco-Ottoman Siege of Nice in 1543, and he led it to victory at the Battle of Ceresole in 1544.
His early death at the age of 27 was caused by an accident – falling of a heavy chest – in the castle La Roche-Guyon.